Date of Award
1977
Document Type
Thesis
Degree Name
Master of Arts
First Advisor
V. Minnich
Abstract
Agatha Rollins’ 1977 master’s project, Electronic Cell Pattern Recognition Manual, explores the feasibility of using the Technicon Hemalog "D" Differential Analyzer as a diagnostic tool for hematologic diseases. The analyzer identifies white blood cell types through electronic signals based on their scatter and absorbance patterns in the peroxidase channel. Rollins hypothesized that similar diseases would yield consistent, recognizable electronic patterns, enabling identification without manual microscopy.
The project involved analyzing patients with various conditions—including chronic lymphocytic leukemia, myeloperoxidase deficiency, eosinophilia, and several leukemias—by comparing manual differential counts with Hemalog “D” results. Rollins documented and evaluated x-y display signatures for each disease, seeking pattern commonalities across cases. She also reviewed literature supporting cytochemical staining and automated analysis as valuable diagnostic aids.
One of the project's standout observations was the distinct spike pattern in chronic lymphocytic leukemia cases, suggesting the potential for automated pattern-based recognition. While the manual count remained the gold standard, Rollins argued for the Hemalog “D” as a valuable supplement—especially in identifying atypical or abnormal patterns missed in routine lab work.
Her work represents an early effort to blend diagnostic hematology with machine-assisted pattern recognition, foreshadowing current developments in AI-driven medical diagnostics.
Recommended Citation
Rollins, Agatha, "Electronic Cell Pattern Recognition Manual" (1977). Theses. 1319.
https://digitalcommons.lindenwood.edu/theses/1319
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