Safety concerns associated with BACE1 inhibitors - past, present and future
Document Type
Article
Publication Title
Expert Opinion on Drug Safety
Abstract
Introduction
BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) inhibitors have shown promise in treating Alzheimer’s disease (AD) by reducing amyloid-beta (Aβ) production. However, clinical trials of inhibitors like atabecestat, verubecestat, and lanabecestat have faced challenges, including limited efficacy and significant adverse effects.
Areas Covered
This narrative review discusses randomized-controlled trials of BACE1 inhibitors. Literature searches were conducted using PubMed and Web of Science for studies from 2010 to 2024. Association with BACE1’s widespread expression beyond the brain shows adverse effects such as anxiety, depressive symptoms, and hepatotoxicity.
Expert Opinion
The trial results underscore the need for CNS-specific BACE1 inhibitors to reduce adverse effects. Future research should focus on optimizing drug design and identifying additional therapeutic avenues, such as prostate cancer and insulin resistance.
DOI
https://doi.org/10.1080/14740338.2025.2467811
Publication Date
2-2025
Recommended Citation
Naidu, Aniketh; Silverglate, Bret; Silverglate, Mary; and Grossberg, George T., "Safety concerns associated with BACE1 inhibitors - past, present and future" (2025). Faculty Scholarship. 719.
https://digitalcommons.lindenwood.edu/faculty-research-papers/719
