Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle
Document Type
Article
Publication Title
Exercise and Sport Sciences Reviews
Abstract
Retrotransposons are gene segments that proliferate in the genome, and the Long INterspersed Element 1 (LINE-1, or L1) retrotransposon is active in humans. Although older mammals show enhanced skeletal muscle L1 expression, exercise generally reverses this trend. We hypothesize skeletal muscle L1 expression affects muscle physiology, and additional innovative investigations are needed to confirm this hypothesis.
DOI
doi: 10.1249/JES.0000000000000301
Publication Date
6-2022
Recommended Citation
Romero, Matthew A.; Mumford, Petey W.; Roberson, Paul A.; Osburn, Shelby C.; Young, Kaelin C.; Sedivy, John M.; and Roberts, Michael D., "Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle" (2022). Faculty Scholarship. 426.
https://digitalcommons.lindenwood.edu/faculty-research-papers/426