Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle
Exercise and Sport Sciences Reviews
Retrotransposons are gene segments that proliferate in the genome, and the Long INterspersed Element 1 (LINE-1, or L1) retrotransposon is active in humans. Although older mammals show enhanced skeletal muscle L1 expression, exercise generally reverses this trend. We hypothesize skeletal muscle L1 expression affects muscle physiology, and additional innovative investigations are needed to confirm this hypothesis.
Romero, Matthew A.; Mumford, Petey W.; Roberson, Paul A.; Osburn, Shelby C.; Young, Kaelin C.; Sedivy, John M.; and Roberts, Michael D., "Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle" (2022). Faculty Scholarship. 426.